Dr Sankar Ramachandran:

Institute of Infectious Disease and Molecular Medicine, Applied and Proteomics Group, Department of Medical Biochemistry, University of Cape Town

Clinically relevant receptors in colorectal cancer.

Using mass spectrometry the research focuses on analysing colorectal cancer tissues to identify altered protein expression that can predict potential biomarkers of response to chemo and radiotherapy in these patients. We aim to discover the proteome and biomarkers from colorectal cancer patients who received either chemo or radiotherapy, before surgery and to correlate this to clinical outcome.


Dr Serah Kimani:

Department of Human Biology, University of Cape Town

Potential inhibitors for oncogenic transcription factors, TBX2 and TBX3

The focus is on characterizing two proteins, TBX2 and TBX3, whose levels are frequently elevated in several cancers and leads to the development and progression of cancer. They have been identified as drug targets for anti-cancer therapies. We seek to develop small molecule compounds that may be used as drugs to inhibit their activity, thereby contributing to more effective anti-cancer therapies.